国际眼科纵览 ›› 2023, Vol. 47 ›› Issue (5): 413-417.doi: 10.3760/ cma.j.issn.1673-5803.2023.05.005

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血小板在早产儿视网膜病变发生发展中的作用

孔佳怡  李曼红  张自峰  王雨生   

  1. 空军军医大学西京医院眼科 全军眼科研究所,西安 710032
  • 收稿日期:2023-04-06 出版日期:2023-10-22 发布日期:2023-11-06
  • 通讯作者: 张自峰,Email:zzffmmu@163.com E-mail:zzffmmu@163.com
  • 基金资助:
    国家自然科学基金(81770936);西京医院临床应用研究课题(JSYXM02)

Role of platelets in retinopathy of prematurity

Kong Jiayi, Li Manhong, Zhang Zifeng, Wang Yusheng   

  1. Department of Ophthalmology, Xijing Hospital, Air Force Medical University, Eye Institute of PLA, Xi’an 710032, China
  • Received:2023-04-06 Online:2023-10-22 Published:2023-11-06
  • Contact: Zhang Zifeng,Email:zzffmmu@163.com E-mail:zzffmmu@163.com
  • Supported by:
    retinopathy of prematurity; platelets; angiogenesis

摘要: 早产儿视网膜病变(retinopathy of prematurity,ROP)是目前世界范围内儿童盲的首位病因,新生血管形成是其发生发展的重要病理因素。血小板是一种由成熟巨噬细胞胞浆脱落产生的细胞碎片,可参与止血凝血、伤口愈合、炎症反应和肿瘤转移等生理病理过程,并能通过调控血管生成相关因子和相关细胞在血管生成过程中发挥重要作用。近年研究提示,血小板在ROP发生发展中发挥着重要作用,可能为ROP早期筛查和血小板输注治疗提供新的思路。

关键词: 早产儿视网膜病变, 血小板, 血管生成

Abstract: Retinopathy of prematurity (ROP) has already become the leading cause of blindness in children worldwide, while neovascularization is the significant pathological cause of ROP occurrence and development. Except for participating in coagulation and hemostasis, wound healing, inflammation and tumor metastasis, platelets, the cellular debris produced by mature macrophages, play an important role in angiogenesis through regulating angiogenesis related factors and cells. Researchers have shown that the role and variation of platelets in ROP may provide new ideas for early screening and treatment with platelets infusion.

Key words: retinopathy of prematurity, platelets, angiogenesis